Boston Analytical adds New Laboratory Instruments for Expanded Capabilities in Elemental Analysis

(Salem, NH) August 5, 2016 — Boston Analytical has added a few new tools to bolster their capabilities in pharmaceutical materials characterization. Boston Analytical has brought on instrumentation for differential scanning calorimetry (DSC), thermogravimetric analysis (TGA) and Carbon, Hydrogen, Oxygen, Nitrogen, and Sulfur (CHONS) elemental analysis. These instruments were chosen to expand Boston Analytical's capabilities in characterization of raw materials, process intermediates, drug substances and drug products.

Elemental Analyzer (EA) – Perkin Elmer Series II 2400 CHNS/O Elemental Analyzer

The Perkin Elmer Series II 2400 CHNS/O (CHONS) Elemental Analyzer can be used to measure the relative concentration of the elements carbon, hydrogen, nitrogen, sulfur and oxygen. These measures can be an important quality control characteristic of the material, and can help in identification of unknown compounds. The 2400 Series II has three main analysis approaches (CHN, CHNS or Oxygen mode) which allow for the measurement of each of these elements in the most efficient and accurate manner. The instrument measures products of combustion to detect carbon, hydrogen, nitrogen, and sulfur content, while oxygen content is determined by pyrolyzation of the sample and measuring the resultant products.

Differential Scanning Calorimeter (DSC) – Perkin Elmer DSC 8000

Another important addition is a Perkin Elmer DSC 8000 differential scanning calorimeter. The DSC applies heat to both the sample and a reference material, and then measures the different amount of heat required to increase the temperature of each. The resultant Temperature vs. Time curve is useful in detecting phase transitions such as melting from a solid to a liquid, vaporization, desorption, evaporation and glass transitions within solid samples. Differential scanning calorimetry can also be used in formulation development to show whether excipient chemicals added to the product interact with the active ingredients in a way that may have deleterious effects on the final drug product.

Thermogravimetric Analyzer (TGA) – Perkin Elmer TGA 8000

Another instrument Boston Analytical has acquired for thermoanalysis of drug ingredients and final products is also from Perkin Elmer: The TGA 8000 thermogravimetric analyzer. The TGA is used to measure melting point and other phase transitions, but using a different approach than the DSC. Thermogravimetric analysis can measure loss of volatile components in a material and chemical events like dehydration, decomposition and solid-gas reactions such as oxidation and reduction.

These three new instruments enhance Boston Analytical's arsenal of tools which can be used for analysis of raw materials, process intermediates, excipients, and final drug products, allowing Boston Analytical to achieve even better support for drug development and characterization.

For more information on Boston Analytical's physiochemical instrumentation, elemental analysis services, thermogravimetric analysis services, and other characterization capabilities please contact them today.

More About Boston Analytical

Boston Analytical, the Life Sciences Division of Alpha Analytical, is a cGMP compliant, FDA/DEA registered, ISO/IEC-17025:2005 certified analytical laboratory located in Salem, NH. Boston Analytical provides testing services to Pharmaceutical and Medical Device companies worldwide including Analytical Testing and Method Development, Microbiological Testing and EM Services, Stability Testing & ICH-compliant Storage, and Extractables & Leachables Studies.